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Copyright © 2002 Dr FMD Ismail
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Research Interests:
- Measurement of fundamental rate constants using nanosecond pulsed radiolysis.
- Laser and Raman Spectroscopy.
- Drug design, QSAR & biophoric maps.
- Structural elucidation.
- focused microwave accelerated reacctions.
- Prediction of reaction pathways using Density Functional Theory.
- Design, Synthesis, Pharmacological
Evaluation and Molecular Modelling of mono- and
bis-4 aminoquinoline antimalarials.
- Synthesis of Novel Topoisomerase II
poisions.
- Synthesis and anticancer activity of
diazaanthracenes, quinolines and acridines.
- Synthesis of trioxanes and trioxolanes related to artemisinin and Yingzhaosu.
- Synthesis of ANtioxidants related Vitamin E.
- Construction of fluorinated
N-arylphenazines.
- HIV Integrase Inhibitors.
- Treatment of Lupus with 4-aminoquinolines.
- Naldixic acid derivatives.
- Molecular modelling of porphyrins.
- Synthesis and biological evaluation of
tubulin disrupters.
- Structure-Activity-Toxicity Relationships.
- Multidimensional NMR experiments to
elucidate natural product structure.
- 17O NMR Studies of Artemisinin and related
1,2,4-trioxanes.
- INADEQUATE Spectroscopy.
- Discovery and Optimisation New and Exisiting
Atom Efficient Industrial Processes
Several patents have been granted including
those concerning
Immunostimulants, Antimalarials and
Antioxidants. For instance, compounds which
consist of an antioxidant moiety chemically linked
to the precursor moiety which is capable of
targeting specific populations of cells by
exploiting endogenous uptake systems for
biological chemicals are useful in the treatment
of neurodegenerative disorders.These include
Parkinson's disease, Alzheimer's disease and
neuropathological conditions induced by
amphetamines such as MDMA. If you want to study
for a higher degree or wish to collaborate on a
specific project.
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Enquiries to:
Dr F M D Ismail
Department of
Pharmacy and Chemistry
e-mail :
F.M.Ismail@livjm.ac.uk
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